Dark Genome Biomarker Discovery

Our End-to-End Dark Genome Biomarker Solution

Our platform, built around our TEnex technology, transforms raw transciptomics data into a curated set of TE-derived biomarkers and targets, optimized for biological relevance and clinical utility.

Key Capabilities

Deep Repetitive Genome Profiling

Comprehensive quantification of TE expression and activity across your samples
Characterization of TE families, subfamilies, and locus-specific events
Annotation of TE–gene regulatory relationships to reveal hidden drivers of phenotype

Biomarker Discovery in the Dark Genome

Identification of TE-derived signatures associated with disease, response, or resistance
Discovery of TE-based diagnostic, prognostic, and minimal residual disease markers
Integration of TE features with gene expression, mutations, and clinical metadata

AI-Enhanced Modeling and Interpretation

Machine-learning models that combine sequence, structure, and genomic context of TEs
Predictive models to prioritize TE loci with the highest likelihood of clinical relevance
Pattern discovery to reveal TE networks, regulatory modules, and pathway-level effects

TEnex: Purpose-Built for Transposable Elements

We have developed TEnex, a set of optimized, peer-reviewed pipelines and programs dedicated to the analysis of transposable elements in -omics data.

With TEnex you benefit from:

A curated, up-to-date TE reference database covering major families and subfamilies
Proven workflows hardened on real biological and clinical datasets
Over 10 years of experience at the forefront of TE biology and dark genome analytics

Personalized Solutions for Your Project

Whether you are exploring TEs for the first time or expanding an established dark-genome program, we provide end-to-end support tailored to your needs:

Project Types

Oncology: TE activation signatures, immune modulation, and neoantigen discovery
Neurology & psychiatry: TE dysregulation in neurodegenerative and neurodevelopmental disorders
Immunology & infection: TE responses to pathogens and immune stimulation
Cell & gene therapy: TE-derived safety, off-target, and insertional risk markers

What We Customize with You

Data types and platforms (bulk RNA-seq, single-cell, spatial, ChIP/ATAC, WGS)
Biomarker use cases (diagnostic, prognostic, predictive, pharmacodynamic)
Computational environment (on-premise, cloud, or hybrid setups)
Timelines, reporting format, and level of interpretability required by your team

Illuminate the Dark Genome

Let us be your partner in bringing the repetitive genome into focus. Our dark-genome biomarker solution can help you:

Reveal biology others miss by systematically analyzing TE-rich regions
Accelerate biomarker discovery with AI-driven prioritization and in-silico screening
De-risk downstream development with robust, well-characterized TE signatures
Optimize resource allocation by focusing experiments on the most promising candidates

Partner with us to turn the dark genome into a new source of actionable biomarkers—for better decisions, better programs, and better outcomes for patients.

Contactez-nous

Nos locaux:

Nexco Analytics Bâtiment Alanine Route de la Corniche 5B 1066 Epalinges, Switzerland

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+41 76 509 73 73

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contact@nexco.ch

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