Advanced Bioinformatics

Transposable elements (TEs) constitute 60% of the human genome, yet they are usually discarded from analyses due to their repetitiveness and complexity. As TEs can regulate gene expression and act as harbors for transcription factors, their analysis can help understand the biology hidden in your data. Their expression in diseases and their peculiar sequences make them great target for biomarkers discovery and therapy. We have developed TEnex, a set of optimized peer reviewed pipelines and programs to analyze transposable elements in -omics data. Take advantage of our curated TE database and 10years of experience in the field.

Transposable elements (TEs) are no longer considered inert genomic repeats. A growing body of literature demonstrates that they actively shape gene regulation by providing promoters, enhancers, splice sites, and transcription factor binding motifs or making novel chimeric transcripts. TE-derived regulatory elements are now known to be co-opted by the host genome and integrated into core transcriptional networks. In cancer and other diseases, TE expression is frequently dysregulated. Specific TE families show robust, reproducible activation patterns across tumor types, often correlating with epigenetic alterations, immune activation, and patient outcome. These properties make TEs powerful biomarkers for diagnosis, prognosis, and treatment response, as already demonstrated in multiple large-scale transcriptomic studies. Analyzing TEs requires dedicated methods that account for their repetitive nature, tricky normalization, and family-level regulation. Generic RNA-seq pipelines fail to capture this signal. With over a decade of expertise in TE biology and purpose-built analytical frameworks, Nexco Analytics is uniquely positioned to help you unlock the biomarker potential hidden in the dark genome.

In the realm of bioinformatics, customized solutions driven by technological advances outshine standard approaches. When complexities arise and standard methods fall short, which is most of the cases, advanced analyses become imperative. Our services offer tailored insights that transcend conventional limitations, ensuring your data is fully understood and enabling groundbreaking research strides. Whether you need a custom pipeline built from scratch or advanced techniques applied to your existing data, we work closely with you in a collaborative approach to deliver the solution that best fits your research goals.