Standard NGS analysis directly from your web browser

As Next Generation Sequencing (NGS) technologies have advanced, we’ve seen a dramatic reduction in costs and a corresponding surge in data volume. What once cost millions of dollars to sequence a complete human genome can now be done for less than $1,000. This remarkable shift has made sequencing more accessible to a wider range of laboratories, paving the way for precision medicine.

With the increase in sequencing capabilities, the demand for streamlined and standardized analysis has grown significantly. Recognizing this need, Nexco has stepped forward with a solution. We proudly present ONex, our AI-driven platform designed to offer comprehensive, standardized analysis of omics data. In final development, ONex is our commitment to simplifying and enhancing the data analysis process, ensuring that the potential of NGS can be fully realized in advancing medical research and patient care.

From Raw Data to Biological Insights

Over time, numerous tools for processing Next Generation Sequencing (NGS) data have emerged, becoming increasingly user-friendly and deployable. While many of these tools are proven to be effective in comparative studies, their setup and operation often demand significant time and specialized expertise.

At Nexco, we have spent years refining our NGS data analysis pipelines, achieving a level of quality recognized in many peer-reviewed journal publications. A key feature of our pipelines is their speed, a crucial factor developed in response to our need to efficiently process vast datasets comprising thousands of samples. We developed methodologies for transcriptomics (RNA-seq, BRB-seq, scRNA-seq, …), epigenomics (ChIP-seq, ATAC-seq, BS-seq, …), genomics (WGS, WES, …) or proteomics (MS/MS, SILAC…) which we all plan to support.

In 2024, we believe that access to comprehensive, standard analysis shouldn’t be a barrier. That’s why we’ve integrated our advanced pipelines into the ONex platform we are currently developing. Now, you can securely upload your data to our servers, located in Switzerland — a country renowned for its stringent data privacy laws. With ONex, you can effortlessly run our optimized pipelines, transforming your raw or pre-processed data into valuable insights, without the complexities traditionally associated with NGS data processing.

Interactive Results and Project Management

We’ve designed a dynamic and interactive platform where, after processing your raw data, you can tailor the analysis to your specific needs and interactively explore the desired results.

Our system supports a range of functionalities, from basic quality control to more sophisticated analyses like gene set enrichment and cell-type deconvolution. This flexibility allows you to unlock the biological insights contained within your sequencing data effectively.

Through our user-friendly interface, you can efficiently manage your projects, collaborate with your team, initiate additional analyses, delve into the results, and much more, ensuring a comprehensive and seamless research experience.

Managing Challenging Data and Pursuing Customized Analyses

Despite meticulous sample preparation and care, data issues can still arise. Our quality control system is designed to identify anomalies, promptly alerting you to any potential concerns along with suggested solutions.

Should any issues occur, our dedicated team is always on hand to help. We specialize in resolving data problems, employing a variety of custom methods, including batch correction and imputation, to salvage and restore problematic datasets.

If your requirements extend beyond standard analysis, our team of experienced data analysts and bioinformaticians is ready to collaborate with you to develop a tailored solution that addresses your specific biological queries. Having worked with numerous academic laboratories, biotech companies and hospitals over the years, our experts are adept at understanding your unique research questions and selecting the most effective analytical approaches to explore them within your dataset. Since your data is already hosted on our servers, initiating advanced, customized analyses is a streamlined and straightforward process.

For comprehensive information about ONEx, visit our website at https://nexco.ch/onex. We also invite you to contact us for early access and to contribute to the ongoing development of this innovative platform.

References

• The Cost of Sequencing a Human Genome
• Systematic comparison and assessment of RNA-seq procedures for gene expression quantitative analysis - Scientific Reports